C-reactive protein (CRP) - a protein substance, a glycoprotein, which is located in the plasma and refers to acute phase indicators indicating the inflammatory process in the body.In fact, its presence using certain techniques, the practice of medicine is an indicator of inflammation, necrosis or injury, as it is detected faster than the increase in ESR.
Its appearance plays a protective role in the blood, because it has the ability to bind bacterial streptococcal polysaccharide, which is an early reaction to the introduction of infection.
C-reactive protein refers in its biochemical structure pentraxins family, whose characteristic feature is the sharp reaction to immunological processes, but only CRP is considered to be a major component in communication between innate and adaptive immunity.Its task is to define the body part in microorganisms and their uptake by phagocytes during interaction of T and B lymphocytes.
synthesis of the protein that occurs in hepatocytes, triggered by the introduction i
When it is necessary to determine the CRP?
What is C-reactive protein, if it is found in the blood?Using diagnostic purposes the definition of this protein helps to identify these abnormalities in the body:
- infectious processes of any origin;
- autoimmune diseases;
- check the patient's condition after the operation;
- dynamics of the flow of certain diseases;
- assessment of the risk of vascular pathologies.
synthesis of this protein is produced in the liver and in the absence of an inflammatory reaction in the blood rate is 0.5 g / ml.From a person's age, this figure does not.
In some cases, can increase the c-reactive protein?
If you have an acute infection-reactive protein in the blood will be increased only after 6 hours, but after two days, its concentration can be increased up to 100 times.
This material is considered to be a non-specific marker of inflammation, because it a significant deviation from the normal upward observed in all the processes that occur in the body, including cancer pathology and necrosis.
But most revealing is when the C-reactive protein is elevated in bacterial infectious processes.
This phenomenon can also occur in the following pathological conditions:
- acute myocardial infarction;
- exacerbation of chronic disease (immune-related);
- trauma, burns, surgery;
- pathological changes of cardiac muscle under the influence of infectious processes;
- rheumatoid arthritis;
- pankretita acute form, including the development of necrosis of the pancreas;
- oncopathology and metastasis;
- hormonal background in women;
- active rheumatic joints.
Sometimes increase C-reactive protein may be accompanied by some conditions not associated with pathological abnormalities.This is - intense physical activity, pregnancy, treatment with hormone replacement agents.
C-reactive protein in the blood may be reduced when used during the treatment of inflammatory drugs, beta-blockers, glucocorticoids, statin therapy.
importance of determining this index is still in the fact that his change may occur in people with normal cholesterol rates and the complete absence of clinical symptoms, but point to a high probability of developing hypertension, stroke or heart attack and other diseases that lead tosudden death.
use of drugs that reduce cholesterol and normalizing blood rheology indicators, as well as regular exercise, proper nutrition reduce the amount of c-reactive protein, and thus help to reduce the likelihood of vascular pathology.
what purpose used this study?
Determination of blood C-reactive protein helps to assess the risk of heart and vascular disease in conjunction with other research methods.These data allow us to estimate the probability of the development of a variety of complications in people who have had a recent heart attack or stroke.
Some experts use the value of the indicator to assess the effectiveness of the prescribed treatment and recovery dynamics.Thus, the appointment of antibacterial therapy, elevated or increasing over time indicators of this protein shows its inefficiency and the need for urgent revision of the form and mode of administration of the drug.
investigate the c-reactive protein, and for the differential diagnosis of bacterial and viral infections.When the viral infection of his numbers increased slightly or not different from the norm.
Increase of this indicator in infants up to 12 mg / l, says the development of sepsis, and requires urgent action.
During a heart attack within 18-36 hours is an increase in CRP, and then to about 20 the day it is somewhat reduced, and becomes normal in a month or 40 days.In recurrent MI, again determined by high C-reactive protein, anginal attacks do not cause its increase, that is an additional feature in the differential diagnosis.
After severe trauma, burn tissue damage, septic complications, CRP can rise to extremely high digits - 300 g / l or more.The success of treatment is determined by the decrease to normal values by 6-10 hours after initiation of therapy.Like this?Share with friends and acquaintances: