Biliary cirrhosis : forms of the disease and symptoms

Biliary cirrhosis - is actively developing a chronic disease process is destructive-inflammatory nature that damages the bile channels within the liver and provokes cirrhosis.

Forms pathology

Primary biliary cirrhosis is an autoimmune liver disease and manifests itself as a chronic purulent inflammation of the bile ducts, which for a long time does not cause injury symptoms.That inflammation and subsequently becomes the main cause of liver cirrhosis and forming it affects mainly female aged 40 to 60 years.

often to the development of the disease ascites is attached - is fluid accumulation in the abdomen, as well as hepatic encephalopathy, affects the human brain, bleeding from the affected veins in the esophagus and stomach.

The secondary biliary cirrhosis is a progressive pathology that develops against the backdrop of prolonged violation of bile excretion of the major bile channels.This form mainly affects the male body at the age of 30 to 50 years.

Symptoms pathological condition

primary biliary cirrhosis may not cause any symptoms, but it can progress, as slow and fast.In the absence of any symptoms of pathology can be diagnosed based on laboratory diagnosis - that is, with an increase in alkaline phosphatase activity, with an increase in the concentration of cholesterol.

Typical symptoms of primary biliary cirrhosis - is itching of the skin prior to yellowing of the skin and sclera shade. Skin Itching may disturb the patient for several months or even several years, and therefore, patients are often quite unsuccessfully being treated by a doctor dermatologist.Incessant itch provokes a large number of scratches on the arms, legs and back, and jaundice usually manifests itself only six months or even a year and a half after the itching.In addition to the primary form of cirrhosis may develop itching pain in the right hypochondrium and increased spleen size.

Increase in blood cholesterol concentrations often provokes the formation of yellow spots on the skin.In addition to skin disorders in the development of the disease and refers the formation of spider veins, redness on the palms.Times condition is accompanied by myalgia and numbness of the extremities, changes in the shape of fingers, etc.

In the expanded stage of the disease there is an increase of jaundice, much general condition worsens, there is depletion of the body. Akvtino developing cholestasis causes dyspeptic disorders - such as diarrhea.Complication symptoms biliary cirrhosis also include the formation of gallstones, ulcers in the duodenum.

In the later stages of the disease a person develops osteoporosis, osteomalacia, may occur pathological fractures of limbs, hemorrhage, varicose veins in the esophagus.Lethal outcome comes as a result of liver failure due to portal hypertension, ascites and gastrointestinal bleeding.

How to implement the right treatment process

main objectives of the treatment process for biliary cirrhosis - a stopping or regression of pathological disorders in the body, treatment of already developed complications such as cholestasis or hepatic failure or organ transplantation.Drinking of alcoholic beverages or any toxic drugs to be excluded.

ursodeoxycholic acid inside during the meal helps to reduce damage to the liver, to extend the patient's life and delay the timing of liver transplantation, 20% of patients, even after four months of treatment no improvement in terms of the biochemical analysis of blood.It can be concluded.What is the situation actively progressing disease, and some time later the patients need urgent liver transplant.

Other drugs used to treat the liver, do not affect the overall clinical outcome and can give a contradictory effect.Among such drugs should be classified as colchicine, penicillamine, methotrexate, and others.

Itchy skin can be controlled thanks to cholestyramine, taking it for 6 - 8 g twice a day.Some patients reported a decrease in pruritus during treatment with ursodeoxycholic acid in conjunction with UV exposure.Others - after receiving opiate antagonists or rifampin.

Lack of fat requires additional treatment calcium and vitamins A, E, K and D. In an osteoporosis with calcium preparations necessarily assigned reception of vitamin D, the implementation of medical gymnastics and estrogens.In advanced stages of disease is necessary to conduct the treatment of portal hypertension and cirrhosis.

organ transplant can give a surprisingly positive results.A common indication for transplantation organizations are frequent bleeding from varicose veins, the unbearable itching of the skin, shape of refractory ascites and encephalopathy liver.the survival rate of patients after one goal after organ transplants exceeds the figure of 90%, the survival rate at five years is more than 80%.The primary form of biliary cirrhosis may develop again in about 15% of cases within the first few years after surgery, but these data were not officially recognized by the world medical science.

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