mesangiocapillary glomerulonephritis differently called lobular - it can not meet very often, but it affects the disease, both adults and children.With regard to the prognosis of the disease, then this kind can be considered the most unfavorable.Idiopatichskaya form is manifested in man between the ages of 8 and 30 years.
Clinical characteristics vary depending on the severity of the disease: typically urinary syndrome with minor proteinuria and blood in the urine or acute nephritic syndrome - swelling, hematuria, severe proteinuria, often accompanied by the formation of kidney failure.
There are three kinds of manifestations mesangiocapillary jade.By clinical signs are identical, but differ slightly in their laboratory parameters and the results of transplantation.Basically diagnosed first and second types of patients.
Causes of pathology
mesangiocapillary Causes of glomerulonephritis are bacterial or viral infections.There are cases when the body's failure correlated with streptococcal infections
also in case of glomerulonephritis mesangiocapillary a role belongs to hereditary factors.The disease most often affects the male body at a young age, as well as the child's body, and therefore, the disease is rarely diagnosed in the elderly.
Manifestations of the disease Symptoms of this disease is not different in the development of different morphological variants of the disease.
For mesangiocapillary glomerulonephritis characterized by hematuria, proteinuria, and strongly expressed nephrotic syndrome, often in the acute course, as well as deterioration of renal function.
In 10% of cases in adults and 5% of cases in children mesangiocapillary glomerulonephritis causes of nephrotic syndrome.Often there is a persistent increase in blood pressure.The combination of characteristics such as nephrotic syndrome, hematuria and high blood pressure should alert the clinician to diagnose mesangiocapillary glomerulonephritis.It may also develop anemia, correlated with the presence of active complement to the red blood cells.
With the development of type 2 disease are often observed symmetrical lesion of the retina in the eyeball non-inflammatory nature, having a yellow tint.
Often during mesangiocapillary glomerulonephritis begins with the development of acute nephrotic syndrome with an unexpected expression of hematuria, severe proteinuria, edema and high blood pressure rates.Sometimes physicians in this situation wrongly diagnosed with the acute form of jade.One-third of all patients pathology manifests rapidly developing renal insufficiency.
Almost always mesangiocapillary glomerulonephritis combined over systemic disease or infection, so for each individual case of illness will require a thorough search of concomitant diseases.Pathology is constantly progressing and only rarely possible to achieve spontaneous remission.
Mazangiokapillyarny glomerulonephritis is considered the most unfavorable form, in the absence of appropriate treatment renal failure occurs after 10 years in 50% of cases, and 20 years later - in 90% of cases.
As a characteristic of this disease, you can select it stepwise progression and a sharp deterioration in kidney function in some patients.
process of treating disease
process of treatment of the disease is still not sufficiently efficient and incomplete.The most unfavorable signs for predicting considered a violation of the kidneys, and the discovery of nephrotic syndrome from the very beginning of developing the disease.
Also, there is always the risk of a secondary form mesangiocapillary glomerulonephritis requiring therapeutic treatment.In such manifestations the patient is assigned to antibiotic therapy, chemotherapy and plasmaphoresis.
Patients with mild proteinuria do not require active treatment.When blood pressure increase requires strict monitoring by a specialist, and receive special preparations.In severe proteinuria is commonly used cytostatic therapy and prednisone, or a combination of such drugs as dipyridamole and aspirin.
At the first sign of nephrotic syndrome and maintaining the normal operation of kidney are treated with corticosteroids.With this treatment results are better therapy for those patients who have previously been treated for a long time steroids.
In recent years, doctors detection nephrotic syndrome and deterioration of kidney function at the beginning of the disease often prefer treatment of immunosuppressive effects on the body.Adult monotherapy with corticosteroids is not as effective as compared to the children, so use only the first aggravation of nephrotic syndrome under normal kidney function and no increase in arterial pressure.