How is kidney fibrosis, its causes and consequences of the defeat of the body

renal fibrosis is the excessive formation of connective tissue in the kidney, in the absence of recovery signs.

Often this pathology combined with any autoimmune processes in the body.Usually.proliferation of connective tissue affects not only the kidneys but also other organs such as the pancreas, intestines.The disease initially affects only one kidney.But later strikes and other.Such flow pathology observed in one third of patients.Bodies which have suffered from fibrosis, shrivel to a strong increase in the size of the pelvis.And the internal structure of the affected kidney is completely broken.Also hit and urinary channels, decreases their lumen, thicken walls.Vessels supplying the kidney with blood, are also subject to disease.

With the development of fibrosis around the kidneys, a large number of connective tissue.Sometimes this process is observed in long-term use of drugs for migraine or for the treatment of hypertension.

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primary lesion is usually formed in the prescrib

ed place - it is the outer capsule that contains the kidney itself and its fatty capsule.Also a source of primary lesions are retroperitoneal structures or vessels that supply blood to the kidney.

is believed that fibrosis begins to develop due to an allergic reaction, some signs indicate the origin of the autoimmune disease.Malignancies, the impact of chemotherapy on the human body.Irradiation and tuberculosis in the spine can also serve as a causative factor in kidney fibrosis symptoms.

In addition to all of these reasons contribute to the development of fibrosis, trauma, various mechanical stimuli, chronic poisoning of the body, chronic infectious lesions.

Due to the variety of causes of fibrosis disease is classified into primary and secondary form.Primary fibrosis correlated with autoimmune lesions, fibrosis and secondary - with various diseases and pathological conditions of the human body.

As this pathology manifests itself

Symptoms of kidney fibrosis can be quite varied.The patient complains of feeling pain in the lower back, sometimes the pain may radiate to the groin area.Also, the patient may suffer from an excess of fluid in the body.Because blood flow disorders in humans may at any time be taken away arms or legs, changes gait and at times quite swollen legs.

If the disease had no effect on the nerve plexus, the patient ceases to perceive normal ambient temperature conditions of the environment.Also discharge of urine is accompanied by pain and symptoms of kidney failure are formed over time.A man with much weaker, lose your appetite and can not work productively, he has violated the digestive processes.

The development of the disease is due to the relation between the disintegration of collagen and its synthesis.Reversibility of pathological processes, i.e. disappearance of connective tissue formed is dependent on macrophage features that resolves collagen.Also the chemical composition of the base material.

in foci formation of fibrosis different passive and active areas of connective tissue.Active areas rich in cellular elements, and appear in the centers of active fibrosis due to the appearance of fibroblasts in the connective tissue.Passive sites are the result of the collapse of the necrotic foci in the renal parenchyma and contain a small number of cells.

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So, the main symptoms of kidney fibrosis include: low back pain, pain in the groin area, the delay of fluid removal from the body, the violation of blood flow in the legs and swelling, numbness in feet, recurring lameness, pain during urination, loss of appetite, constipation,, sluggish state and apathy.

Implementation of diagnostic measures

In 30% of cases of the disease in patients a doctor can find the seal on the type of tumor in the pelvis or abdomen.

Laboratory blood tests indicate the presence of anemia, moderate concentration of white blood cells, the acceleration of erythrocyte sedimentation.Urine protein detected in this case.In long-term course of the disease increases the concentration ksantoproteinovaya bodies, uric acid and creatinine.

X-ray examination in the development of fibrosis in the kidney will breach formed in the ureters - the ureters may take the form of crimped, narrow or expand, change its location in relation to the spine.When fibrosis of the affected kidney pelvis expanding.

order to identify rules applied renal function renal angiography or radionuclide examination.

the therapeutic process in fibrosis

In acute renal fibrosis patient flow is assigned to the reception of steroid hormones, in chronic held ureterolysis and Activity obstructive processes reduced by nephrostomy or by installing stents.

If you have suspicions about the origin of the disease requires medication, stop taking drugs.Successful therapy is required to stop the development of chronic infectious processes in the organs of the urogenital and digestive system.Treatment of renal fibrosis in the early stages by a high dosage of corticosteroids and absorbable drugs can stop the progression of the disease.

In the later stages of the disease has already implemented such surgical methods of treatment as:

  1. ureterolysis - the process of release of the ureter from the scar tissue that squeezes it.
  2. Nephrostomy - excretion of urine from the kidney through a special drain into the container.
  3. nephrectomy - removal of ureteral and their subsequent replacement by a tube made of plastic - this technology can be used only when a unilateral lesion and if paired organ is functioning properly.
  4. Substitution ureteral segment of the small intestine.
  5. Creating artificial casing around the ureter.
  6. kidney autotransplantation - the process of moving a kidney in the iliac region, when performed reimplantation vessels and ureters.

After the operation the patient is shown taking high doses of corticosteroids to prevent the proliferation of fibrous tissue for two or three months.

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In carrying out medical treatment and surgery is required every six months to conduct an ultrasound examination of the kidneys, take the biochemical analysis of blood and urine tests overall.

If your doctor has prescribed reception gidralazinovyh medicament is initially required to check the condition of the blood vessels, and then regularly to examine the kidneys and urinary channels and stop taking the medication, even at the slightest violation of their work.

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